Clinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer

Abstract FOXA1 is a pioneer transcription Microwave Plate Drive Button factor that is frequently mutated in prostate, breast, bladder, and salivary gland malignancies.Indeed, metastatic castration-resistant prostate cancer (mCRPC) commonly harbour FOXA1 mutations with a prevalence of 35%.However, despite the frequent recurrence of FOXA1 mutations i

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Case report: A 51-year-old diabetic patient with primary bilateral macronodular adrenal hyperplasia and primary hyperparathyroidism

A 51-year-old female patient with diabetes mellitus and hypertension, exhibiting poor control of blood sugar and blood pressure, was unexpectedly found to have multiple large adrenal nodules, excessive cortisol secretion, and adrenocorticotropic hormone inhibition.Cortisol levels remained unresponsive to both low-dose and high-dose dexamethasone te

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